awọn igbesẹ alaye nipa bi o ṣe le lo awọn microspheres embolic

Awọn Microspheres Embolic jẹ awọn microspheres hydrogel compressible pẹlu apẹrẹ deede, dada didan, ati iwọn calibrated, eyiti o jẹ abajade ti iyipada kemikali lori awọn ohun elo polyvinyl oti (PVA).Embolic Microspheres ni macromer ti o wa lati inu ọti polyvinyl (PVA), ati pe o jẹ hydrophilic, ti kii ṣe atunṣe, ati pe o wa ni awọn titobi pupọ.Ojutu itoju jẹ 0.9% iṣuu soda kiloraidi ojutu.Akoonu omi ti microsphere polymerized ni kikun jẹ 91% ~ 94%.Microspheres le fi aaye gba funmorawon ti 30%.

Awọn Microspheres Embolic jẹ ipinnu lati lo fun imudara ti awọn aiṣedeede iṣọn-ẹjẹ (AVMs) ati awọn èèmọ hypervascular, pẹlu fibroids uterine.Nipa didi ipese ẹjẹ si agbegbe ibi-afẹde, tumo tabi aiṣedeede jẹ ebi ti awọn ounjẹ ati dinku ni iwọn.

Ninu nkan yii, a yoo ṣafihan awọn igbesẹ alaye nipa bi o ṣe le lo Embolic Microspheres.

Igbaradi awọn ọja

O jẹ dandan lati mura syringe 1 20ml, 2 10ml syringes, 3 1ml tabi 2ml syringes, awọn ọna mẹta, scissors abẹ, ife ti ko tọ, awọn oogun chemotherapy, awọn microspheres embolic, media itansan, ati omi fun abẹrẹ.

Igbesẹ 1: Ṣe atunto awọn oogun chemotherapy

Lo awọn scissors iṣẹ-abẹ lati yọ igo oogun chemotherapeutic naa ki o si da oogun chemotherapeutic naa sinu ife ti ko tọ.
Iru ati iwọn lilo awọn oogun chemotherapeutic da lori awọn iwulo ile-iwosan.

Lo omi fun abẹrẹ lati tu awọn oogun chemotherapy, ati pe ifọkansi ti a ṣe iṣeduro jẹ diẹ sii ju 20mg/ml.

Aleyin ti oogun kemoterapu ti tu ni kikun, ojutu oogun chemotherapeutic ti jade pẹlu syringe 10ml kan.

Igbesẹ 2: Iyọkuro awọn microspheres embolic ti o gbe oogun

Awọn microspheres ti a ti mu ni gbigbọn ni kikun, ti a fi sii sinu abẹrẹ syringe lati dọgbadọgba titẹ ninu igo naa,ki o si jade ojutu ati microspheres lati igo cillin pẹlu syringe 20ml kan.

Jẹ ki syringe duro fun awọn iṣẹju 2-3, ati lẹhin awọn microspheres yanju, a ti tu supernatant jade kuro ninu ojutu naa.

Igbesẹ 3: Gbe awọn oogun Kemoterapeutic sinu Embolic Microspheres

Lo awọn ọna 3 stopcock lati so syringe pọ pẹlu microsphere embolic ati syringe pẹlu oogun chemotherapy, san ifojusi si asopọ ni iduroṣinṣin ati itọsọna sisan.
Titari syringe oogun chemotherapy pẹlu ọwọ kan, ki o fa syringe ti o ni awọn microspheres embolic pẹlu ọwọ keji.Nikẹhin, oogun chemotherapy ati microsphere ti wa ni idapo ni syringe 20ml, gbọn syringe daradara, ki o fi silẹ fun ọgbọn išẹju 30, gbọn ni gbogbo iṣẹju 5 lakoko akoko naa.

Igbesẹ 4: Ṣafikun media itansan

Lẹhin ti awọn microspheres ti kojọpọ pẹlu awọn oogun chemotherapeutic fun awọn iṣẹju 30, iwọn didun ti ojutu ti ṣe iṣiro.
Ṣafikun awọn akoko 1-1.2 iwọn didun ti aṣoju itansan nipasẹ ọna stopcock mẹta, gbọn daradara ki o jẹ ki o duro fun awọn iṣẹju 5.

Igbesẹ 5: Awọn microspheres ni a lo ninu ilana TACE

Nipasẹ akukọ iduro ọna mẹta, ta bii milimita microspheres sinu syringe 1ml.

Awọn microspheres ti wa ni itasi sinu microcatheter nipasẹ abẹrẹ pulsed.

Awọn akiyesi itọnisọna:

Jọwọ rii daju iṣẹ aseptic.
Jẹrisi pe awọn oogun chemotherapeutic ti tuka patapata ṣaaju ikojọpọ awọn oogun naa.
Ifojusi ti awọn oogun chemotherapy yoo ni ipa lori ipa ikojọpọ oogun, ifọkansi ti o ga julọ, iyara adsorption, ifọkansi ikojọpọ oogun ti a ṣeduro ko kere ju 20mg / milimita.
Omi ti ko ni ifo nikan fun abẹrẹ tabi abẹrẹ glukosi 5% yẹ ki o lo lati tu awọn oogun chemotherapy.
Oṣuwọn itusilẹ doxorubicin ninu omi abẹrẹ fun abẹrẹ jẹ iyara diẹ ju abẹrẹ glukosi 5%.
Abẹrẹ glukosi 5% tu pirarubicin ni iyara diẹ sii ju omi abẹrẹ lọ fun abẹrẹ.
Lilo ioformol 350 bi iyatọ iyatọ jẹ itara diẹ sii si idaduro awọn microspheres.
Nigbati a ba fi itọsi sinu tumo nipasẹ microcatheter, abẹrẹ pulse ni a lo, eyiti o ṣe iranlọwọ diẹ sii si idaduro microsphere.